In the very near future, a race of huge, insectoid aliens is discovered traveling the galaxy. These aliens, which are known as the Uchuu Kaijuu, or Space Monsters (Note: This name is what they are referred to throughout the series, although the Super Robot Wars games names them the “STMC” or “Space Terrible Monster Crowd”), seem dedicated to the eradication of the human species as the latter takes its first steps away from the solar system, and they are getting closer and closer to Earth. Humanity has responded by developing space going battleships and giant fighting robots. These complex robots—RX-7 Machine Weapons—are actually an advanced type of fighting suit, piloted by a single occupant. As advanced as they are, however, they are being used as trainers for a new weapon, the Gunbuster. However, being relatively new technology, they are difficult to operate (stock shots show pilots working multiple controls with hands and feet, while fingers rapidly operate switches on the hand grips), so pilot candidates are selected from the best and brightest youth on Earth and the Lunar colony. These are trained at schools around the world.
The story begins in the year 2023, not long after the first battles with the aliens, and centers on young Noriko Takaya (タカヤ・ノリコ Takaya Noriko) (voice: Noriko Hidaka). Although Noriko’s father was a famous admiral in the space fleet who went missing following one of the first battles of the war, her own talents as a pilot are questionable—especially when compared to the other students. Nonetheless, she has entered a training school on Okinawa, where she is largely influenced by her instructor, Kouichirou Ohta (“Coach Ohta”), who was one of Admiral Takaya’s crew. He has faith that she will overcome her early clumsiness, while other students are critical of her inability.